منابع مشابه
Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution
The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...
متن کاملSpray-drying Cellulose Nanofibrils: Effect of Drying Process Parameters on Particle Morphology and Size Distribution
Spray-drying was chosen as an appropriately scalable manufacturing method to dry cellulose nanofibril (CNF) suspensions. Spray-drying of two different types of CNF suspensions—nanofibrillated cellulose (NFC) and cellulose nanocrystals (CNC)—was carried out using a laboratory-scale spray dryer. Effects of three spray-drying process parameters on particle morphology and particle size distribution...
متن کاملMechanistic Understanding of Spray Drying
Purpose Spray drying is a growing technology in the pharmaceutical industry with several enabling applications in modern drug delivery. Its understanding is still vastly empirical, mainly in what relates to the particle formation step. Consequently, the design spaces are typically defined through costly experiments and their statistical interpretation. The purpose of this study is to examine th...
متن کاملPowder agglomeration during the spray-drying process: measurements of air properties
Instant food powders are usually produced by spray drying of formulated liquid and powder agglomeration, either into the drying chamber or in an external fluid bed. During spray drying, according to the liquid composition, the viscosity of the initial liquid drops increases more or less rapidly, until the drop surface reaches a rubbery state considered as sticky, before further drying. This sti...
متن کاملModeling of Particle Formation during Spray Drying
A mathematical model for the evaporation of a single droplet, subjected to convective drying in a spray dryer was developed to study the transient phenomena of particle formation. During the constant-rate drying period, the governing equations and boundary conditions were transformed into a form containing Peclet number, Pe, as the main controlling parameter. A numerical solution was developed ...
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ژورنال
عنوان ژورنال: Journal of Industrial & Engineering Chemistry
سال: 1921
ISSN: 0095-9014,1943-2968
DOI: 10.1021/ie50137a024